Effects of statins on dopamine loss and prognosis in Parkinson's disease

SH Jeong, HS Lee, SJ Chung, HS Yoo, JH Jung… - Brain, 2021 - academic.oup.com
… total cholesterol level mediated the associations between statin use … to be associated with
cholesterol level, were entered as … statin increases striatal dopamine content without affecting …

Rosuvastatin improves olanzapine's effects on behavioral impairment and hippocampal, hepatic and metabolic damages in isolated reared male rats

A Mohammed, WM El-Bakly, A Ali… - Behavioural Brain …, 2020 - Elsevier
… such as serotonin (5-HT) and dopamine (DA), and dysfunction of these … In addition, statins
showed neuroprotective effects in … changes among all of the groups where: A and B, SR rats, …

[HTML][HTML] The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action

YM Vuu, A Kadar Shahib, M Rastegar - Pharmaceuticals, 2023 - mdpi.com
… , amongst its two groups, lipophilic statins have a higher ability … of simvastatin for 4 weeks in
SpragueDawley rats restored … significantly increased dopamine content in the striatum [168]…

[HTML][HTML] Update on statin treatment in patients with neuropsychiatric disorders

R Avan, A Sahebnasagh, J Hashemi, M Monajati… - Life, 2021 - mdpi.com
… administration of a selective serotonin reuptake-inhibitor (SSRI) [… association between
anxiety and non-adherence to statinsdopamine concentrations in the prefrontal cortex [114,115]. …

Metformin and fluoxetine improve depressive-like behavior in a murine model of Parkinsońs disease through the modulation of neuroinflammation, neurogenesis and …

IP Mendonça, IHR de Paiva, EP Duarte-Silva… - International …, 2022 - Elsevier
… IL-1β in the prefrontal cortex and iNOS levels in the hippocampus. Both … between
cholinergic and dopaminergic activity in the … reuptake inhibitors (SSRIs) and also has anti-inflammatory …

The anti-inflammatory role of SSRI and SNRI in the treatment of depression: a review of human and rodent research studies

V Dionisie, GA Filip, MC Manea, M Manea… - Inflammopharmacology, 2021 - Springer
… For statins or omega-3 fatty acids similar results were … IL-6 levels in the prefrontal cortex,
hypothalamus, striatum, and … link among inflammation, depression, and monoamine reuptake

Repeated ethanol exposure influences key enzymes in cholesterol and lipid homeostasis via the AMPK pathway in the rat prefrontal cortex

S Xu, SJ Jeong, G Li, JW Koo, UG Kang - Alcohol, 2020 - Elsevier
… study examined the dose- and time-response effects of acute … times per week from Monday
to Friday between 10:00 and 16:… to dopamine D 2 receptors, the dopamine reuptake inhibitor, …

Hyperactivation of the amygdala correlates with impaired social play behavior of prepubertal male rats in a maternal immune activation model

F Vitor-Vieira, FC Vilela, A Giusti-Paiva - Behavioural Brain Research, 2021 - Elsevier
between neutral odors and their nest odor, moderate effect in … cells in the prefrontal cortex
and striatum, but hyperactivation … of dopamine and norepinephrine reuptake transporters, is a …

[HTML][HTML] Immune targets for therapeutic development in depression: towards precision medicine

WC Drevets, GM Wittenberg, ET Bullmore… - Nature reviews Drug …, 2022 - nature.com
… , especially to selective serotonin reuptake inhibitors (SSRIs) … For example, statins, in addition
to their lipid-lowering effects, … connectivity between ventro-medial prefrontal cortex (vmPFC…

Saffron extract-induced improvement of depressive-like behavior in mice is associated with modulation of monoaminergic neurotransmission

C Monchaux De Oliveira, L Pourtau, S Vancassel… - Nutrients, 2021 - mdpi.com
… to hemilaterally collect the frontal cortex (FCx), striatum (Str) … study therefore suggests that,
among the different bioactive … of basal 5-HT levels, but they did reduce SERT reuptake activity, …